Funded Projects

Design and Development of a Next-Generation Modelling and Simulation Platform for Cancer Systems Biology

Principal Investigator’s Organization (PIO):
Lahore University of Management Sciences, Lahore
Principal Investigator (PI):
Dr. Safee Ullah Chaudhary
Project Details:
Start Date 01-Jan-2017
Duration 36 Months
Budget Rs.14.9 million
Status On Going Project
Progress Report View Progress Report
Publications N/A
Thematic Area Health
Project Website
Executive Summary

The proposed project outlines the design and development of a next generation multiscale modelling platform for applications in cancer systems biology. This modelling platform envisages a seamless integration of next generation sequencing and quantitation data from the wet labs and its onward usage for investigating the roles of known oncological factors. A powerful HPC enabled simulation engine will be developed and coupled with an intuitive and customizable GUI. To facilitate in the modelling of complex oncological phenomenon, a programmable interface to the engine and GUI will also be developed. A thorough case study model will also be constructed and made publically available, for exemplifying the rich modelling features provided by the modelling platform. The resulting software and case study model will be made available to the laboratories, research centers, universities as well as the pharmaceutical companies which are aiming to develop or evaluate therapeutic targets as well as drugs for treatment of cancer patients. Upon deployment, the proposed modelling platform will not only assist in the modelling of next generation cancer systems biology data, but will also significantly enhance the throughput of the model building and simulation processes.